Immunoglobulin A vasculitis is a type of small vessel leukocytoclastic vasculitis. It is typically present in childhood with a complete recovery course during adulthood in most cases. However, in adults, the disease is severe and may involve the gastrointestinal and renal systems. It is important for the physicians to determine the involvement of these systems in the initial stage of the disease so that monitoring or treatment can be done to prevent the progression of the disease.

The author of the study, while explaining the gap in the current knowledge, wrote, “The aim of our study was to determine the predictors of gastrointestinal and renal involvement in a prospectively collected cohort of adult IgAV.”

The study included those patients who had histologically proven adult IgAV cases diagnosed between January 2013 and July 2019. The authors comprehensively analyzed the clinical and laboratory parameters as markers to predict GI or renal involvement. Multiple logistic regression analysis was used by the researchers for analysis.

The study involves a 79-month observation period. The researchers identified 214 new IgAV patients. GI tract involvement was observed in 58 patients while renal involvement was observed in 83 patients (with 26 patients have both the GI and renal involvement). The predictors determined for GI involvement through multivariate logistic regression analysis were generalized purpura, the pre-treatment neutrophil to lymphocyte ratio (NLR) > 3.5, and elevated serum IgA levels. Predictors for renal complications include current smoking, generalized purpura, elevated serum IgA, NLR > 3.5, and marginally age.

The study concluded that determining the predictors for GI and renal involvement in such patients helps the doctors in developing the optimum monitoring and treatment strategies which results in a low risk of complications.

Source

Ho?evar, A., Tomši?, M., Jur?i?, V. et al. Predicting gastrointestinal and renal involvement in adult IgA vasculitis. Arthritis Res Ther 21, 302 (2019). https://doi.org/10.1186/s13075-019-2089-2